Comparison of Cholesterol Lowering Diets: Apple, Casein Cytochrom P450 protein and Cholesterol 7α Hydroxylase Activities in Hamsters
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چکیده
منابع مشابه
Cholesterol 7α-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.
Cholesterol 7α-hydroxylase (CYP7A1) plays a critical role in control of bile acid and cholesterol homeostasis. Bile acids activate farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) to regulate lipid, glucose, and energy metabolism. However, the role of bile acids in hepatic inflammation and fibrosis remains unclear. In this study, we showed that adenovirus-mediated overe...
متن کاملOriginal Article Differences in Expression of Cholesterol 7α-Hydroxylase between PHHC and Wistar Rats (cholesterol 7α-hydroxylase gene / gene expression / PHHC rats / hypercholesterolemia)
PHHC rats represent a suitable experimental model of polygenic hypercholesterolemia. It has been found that its metabolic defect is not related to alimentary cholesterol absorption and LDL clearance. We have tested possible changes in cholesterol clearance from the liver to bile acids by analysis of the expression of the cholesterol 7α-hydroxylase (cyp7A1) gene in PHHC (N = 20) and Wistar (cont...
متن کاملCHOLESTEROL LOWERING EFFECT OF RHEUM RIBS IN HYPERCHOLESTEROLEMIC RABBITS
The effects of ethanolic and aqueous extracts of Rheum ribs L. (RR) of the family polygonaceae was studied on serum cholesterol concentration in rabbits. To induce hypercholesterolemia, 0.5 g/kg/day of pure cholesterol powder was given orally to each rabbit for two weeks then cholesterol was halved and each group of animals was treated with a different regimen for another two weeks. Both t...
متن کاملDeficiency of cholesterol 7α‐hydroxylase in bile acid synthesis exacerbates alcohol‐induced liver injury in mice
Alcoholic fatty liver disease (AFLD) is a major risk factor for cirrhosis-associated liver diseases. Studies demonstrate that alcohol increases serum bile acids in humans and rodents. AFLD has been linked to cholestasis, although the physiologic relevance of increased bile acids in AFLD and the underlying mechanism of increasing the bile acid pool by alcohol feeding are still unclear. In this s...
متن کاملLowering of Cholesterol Absorption
THE general association of high blood cholesterol levels with atherosclerosis has been almost universally accepted. Because of this association, doctors attempting to treat the disease have sought means to lower circulating cholesterol and thereby, possibly, to arrest or perhaps even to reverse the process of vascular deposition and narrowing. Numerous drugs employed to the present have achieve...
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ژورنال
عنوان ژورنال: Nature Precedings
سال: 2010
ISSN: 1756-0357
DOI: 10.1038/npre.2010.4205.1